ASTM D7598-16(2017)

ASTM D7598-16(2017) - 15.6.2017

Significance and Use

5.1 Thiodiglycol is a Schedule 2 compound under the Chemical Weapons Convention (CWC). Schedule 2 chemicals include those that are precursors to chemical weapons, chemical weapons agents or have a number of other commercial uses. They are used as ingredients to produce insecticides, herbicides, lubricants, and some pharmaceutical products. Schedule 2 chemicals can be found in applications unrelated to chemical weapons. Thiodiglycol is both a mustard gas precursor and degradant as well as an ingredient in water-based inks, ballpoint pen inks, dyes and some pesticides.4

5.2 This test method has been investigated for use with reagent and surface water.

1. Scope

1.1 This procedure covers the determination of thiodiglycol (TDG) in surface water by direct injection using liquid chromatography (LC) and detected with tandem mass spectrometry (MS/MS). TDG is qualitatively and quantitatively determined by this test method. This test method adheres to single reaction monitoring (SRM) mass spectrometry.

1.2 This test method has been developed by U.S. EPA Region 5 Chicago Regional Laboratory (CRL).

1.3 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.

1.4 The detection verification level (DVL) and reporting range for TDG are listed in Table 1.

TABLE 1 Detection Verification Level and Reporting Range

Analyte

DVL (μg/L)

Reporting Range (μg/L)

Thiodiglycol

100–10 000

1.4.1 The DVL is required to be at a concentration at least 3 times below the reporting limit (RL) and have a signal/noise ratio greater than 3:1. Fig. 1 displays the signal/noise ratio at the DVL.

FIG. 1 Example SRM Chromatograms Signal/Noise at Detection Verification Level

1.4.2 The RL is the concentration of the Level 1 calibration standard as shown in Table 2. The reporting limit for this test method is 100 μg/L.

TABLE 2 Concentrations of Calibration Standards (PPB)

Analyte/Surrogate

LV 1

LV 2

LV 3

LV 4

LV 5

LV 6

LV 7

Thiodiglycol

100

250

500

1 000

2 500

5 000

10 000

3,3’-Thiodipropanol

100

250

500

1 000

2 500

5 000

10 000

1.5 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

1.6 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.

2. Referenced Documents

D3856-11	Standard Guide for Management Systems in Laboratories Engaged in Analysis of Water
D3694-96(2024)	Standard Practices for Preparation of Sample Containers and for Preservation of Organic Constituents
D1129-24	Standard Terminology Relating to Water
D1193-24	Standard Specification for Reagent Water
D2777-21	Standard Practice for Determination of Precision and Bias of Applicable Test Methods of Committee D19 on Water
D5847-22	Standard Practice for Writing Quality Control Specifications for Standard Test Methods for Water Analysis
E2554-18(2024)e1	Standard Practice for Estimating and Monitoring the Uncertainty of Test Results of a Test Method Using Control Chart Techniques (Includes all amendments and changes 10/23/2024).
EPA publication SW-846	Test Methods for Evaluating Solid Waste, Physical/Chemical Methods Available from National Technical Information Service (NTIS), U.S. Department of Commerce, 5285 Port Royal Road, Springfield, VA, 22161 or at http://www.epa.gov/epawaste/hazard/testmethods/index.htm.